An Ambulance Victorian spokesperson said the man had been airlifted to The Alfred hospital with upper body injuries. He was in a serious but stable condition.

7.30pm

The man and woman injured in the crash were being flown to hospital in Melbourne, police confirmed.

Neither of the patients was said to be suffering from life-threatening injuries.

Police said they were starting to investigate the cause of the crash.

"All we can gather is they were heading east (on Duke Street) and something has happened," Central Goldfields Highway Patrol Senior Constable Norm Birthisel said.

"Whether it's a medical episode or something that has happened with the car, we don't know.

"There will be further investigation into the cause. We have to speak with other witnesses who saw the car go off (the embankment)."

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6.30pm

Ambulance Victoria said there were two people in the car - a man and a woman, both aged in their 60s.

The woman was said to be in a stable condition with lower body injuries.

The extent of the man's injuries was not yet known, an Ambulance Victoria spokesperson said.

Paramedics are ready by the roadside with stretchers, and an air ambulance has landed nearby.

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6.10pm

Emergency services are using a ladder to get access to a car that has crashed down an embankment into Forest Creek at Castlemaine.

Members from the CFA, Fire Rescue Victoria, police, Ambulance Victoria and the SES are all on scene.

Traffic is still moving along Duke Street.

Earlier

Emergency services are on scene after a car crashed down an embankment in Castlemaine.

The Country Fire Authority said crews were called to Duke Street about 5.15pm.

Initial reports suggested the car had gone about 15 metres down the embankment, a CFA spokesperson said.

The State Emergency Service is also on scene.

More to come

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