Most of regional Victoria will exit lockdown at midnight on Thursday.
Premier Daniel Andrews announced on Wednesday the current lockdown restrictions would be removed at 11.59pm Thursday, giving regional Victorians greater freedoms.
There are no longer just five reasons to leave your home, with most regional Victorians free to travel around the country areas of the states.
Greater Shepparton will remain under the harsh lockdown conditions, with more than 100 active cases in that area.
Metropolitan Melbourne's lockdown continues indefinitely.
There were 221 cases confirmed in Victoria on Wednesday,
See where all the active cases in Victoria are here
Visitors are still not allowed to homes.
Among the key changes to be implemented will be:
Making the announcement, Mr Andrews said it was cautious reopening, one he hoped would last into the future.
He indicated he would localise any future lockdowns in the regions, as has happened with Shepparton currently.
"If there were an outbreak in another part of regional Victoria then we would look to try to target and localise our public health measures as much as we could," he said.
"That's why in order to keep a handle on what's going on in regional Victoria, people need to get tested as soon as they feel sick."
See the full list of rule changes and restrictions here.
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