An Ambulance Victoria spokesperson said paramedics have treated a man in his 60s after his car hit a tree.
"The man was trapped for some time but only suffered lacerations," the spokesperson said.
The man has been transported to Bendigo Health in a stable condition.
Emergency services are working to free the driver of a car that crashed on the Northern Highway near Runnymede.
CFA, Victoria Police, Ambulance Victoria and SES are on the scene at the intersection of Belt Road and the Northern Highway.
A CFA spokesperson said units were called to the scene at 12.45pm after reports of a car running off the road.
An SES spokesperson said crews assisted with the extrication
"We were waiting on an Ambulance Victoria assessment beofre extricating the person," the SES spokesperson said. "Around 1.30pm, the driver was ready to be removed."