Victoria Police expect to be on scene for the next few hours following the rollover.
Leading Senior Constable Scott Andrews of the Bendigo Highway Patrol said a semi-trailer had driven off the opposite side of the road, lost control and overturned.
The truck and trailer were currently blocking the road.
The driver had gone to hospital as a precaution, he said, with no other people or vehicles involved.
Police would continue their investigations, Leading Senior Constable Andrews said.
Pin denotes road, not location of the crash.
Victoria Police have blocked Axedale-Goorning Road along its length and are urging motorists to find alternative routes.
An Ambulance Victoria spokesperson says one person has been taken to Bendigo Hospital with minor injuries following the crash.
Emergency services have been called to the scene following reports of a truck rollover.
Paramedics, police and the CFA are on scene.
The VicEmergency website is reporting the incident took place on the Axedale-Goornong Road in Fosterville, betweeen Campaspe Road and Fosterville North Road.