UPDATE 4.48pm: Cafe twenty2 owner Tim Carlson said rain had affected the cafe's exterior power box.
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"The power box just shorted and was blowing sparks," he said.
UPDATE 4.18pm: An arcing fuse box has caused a small fire at cafe twenty2.
Bendigo Sergeant Jason Bourke said the cafe had been evacuated.
Powercor is on scene.
UPDATE 4.07pm: Williamson Street is blocked at Hargreaves Street and Pall Mall.
Three fire trucks - one with a cherry picker - and a police car are outside Cafe twenty2.
There is no sign of smoke or fire.
There is fire retardant around the outside of the building.
EARLIER: Emergency crews are responding to a reported structure fire in Williamson Street, Bendigo.
More to come.