UPDATE 2.30pm: Bendigo Detective Senior Constable Michael Thompson said a male in his 30s or 40s had fled the scene with an unknown quantity of cash.
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He said the man was of average height and medium build wearing a hoodie and shorts.
He said at this stage it is too early to tell if the theft was linked to one at the same building a month ago.
EARLIER:
Police are responding to an armed hold up on McIvor Road in Bendigo East.
The post office on the corner of Murphy Street and McIvor Road is set up as a crime scene.
Police are investigating.
More to come.