A white tray truck travelling north along the Calder Freeway collided with a road barrier on Wednesday morning.
The crash occurred just before 5am close to a bridge at Harmony Way, near Castlemaine.
Sergeant Trevor Bailey of Castlemaine police said a male in his mid 20s was the driver of the vehicle. The young man was taken to Bendigo Hospital with minor injuries.
Sergeant Bailey said the front and driver's side of the truck were damaged upon impact with the road barrier.
Police are investigating the cause of the incident.
Sergeant Bailey said any witnesses of the crash should call Crime Stoppers on 1800 333 000 or contact Castlemaine police.