Over the next fortnight, the Bendigo Blood Centre needs about 210 additional people to give blood and plasma.
Lifeblood spokesperson Shae Burns said the demand for blood and plasma continues to grow.
Earlier this month Lifeblood announced a record high spike in blood donation "no shows", with half of the nation's blood donation appointments not being attended.
A new campaign launching today is urging Australians to take the Bloody Oath and make a promise to donate blood.
"We're asking people to take the 'bloody oath' and make a promise to give blood and plasma," Ms Burns said.
"Make a commitment to donate, not just to yourself, but to the community and give hope and life to someone else."
Lifeblood Executive Director of Donor Services Cath Stone said demand for blood was at a 10 year high.
"We need 140,000 new blood donors in 2022 to meet the needs of Australian patients, an increase of 45 per cent," she said.
"We are extremely grateful that people have continued to roll up their sleeves during the pandemic and ensure patients receive the blood and blood products they need, but our existing donors can't do it alone.
"We want to harness the mateship and generosity that carried us through the pandemic and build a community of blood donors who are there to give hope, give joy, give second chances, and ultimately, give life."
Donors can check their eligibility to donate blood online.
To book a donation please call 13 14 95, click here or download the free Donate Blood app.
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