There were 24 new cases of coronavirus recorded in Greater Bendigo, taking the total number of active cases in Greater Bendigo to 221.

Other news: New pandemic laws replace current public health directions, COVID-19 numbers remain steady

The Macedon Ranges Shire recorded four new cases and the Campaspe Shire recorded two new cases.

Zero cases were recorded in the Mount Alexander, Gannawarra, Loddon and Central Goldfields shire's.

Victoria's chief health officer Brett Sutton warned regional Victorians to prepare for an increase in COVID-positive travellers as the state opens up on Friday.

Mr Sutton said protections from first and second-dose vaccination would be critical for every local government area across the state come Friday, especially in the regions.

"The great majority of (regional Victorian towns) above 95 per cent first-dose coverage, that is more equitable for a region in any other jurisdiction in Australia," he said.

"No-one left behind, no LGA left behind, some great mottos to run with."

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"We have some areas of the state that have been relatively untouched by COVID so they have to ready themselves for the fact that they will be more cases out and about across all areas of the state.

"Especially with long weekends with the opportunity for Victorians to travel across the state and so, the protection from first dose and then full dose vaccination is really critical again for every single LGA across the state."

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