Emergency services were called to Axe Creek Road, between Myrtle Creek and Steens roads, shortly before 3pm on Friday.

Bendigo Highway Patrol Senior Constable Levina Bell said the vehicle, a Toyota RAV4, had been travelling towards Junortoun when it went onto some of the gravel on the side of the road.

Senior Constable Bell believed the driver over-corrected and lost control of the vehicle, which crashed into a tree and then went into a wire fence.

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The tree fell on the vehicle and blocked part of the road, Senior Constable Bell said.

A young family from Junortoun was inside the car.

Senior Constable Bell did not believe any of the vehicle's occupants were critically injured.

All four people - a 32-year-old man, a 29-year-old woman, a two-year-old girl and a baby boy - were taken to Bendigo Hospital.

Senior Constable Bell said both the children were correctly restrained, which she believed had saved them.

"We are very, very thankful to members of the public who stopped and had the scene in control when we got there," she said.

Several passing vehicles stopped to help the family.

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Senior Constable Bell said a man parked ahead of the blind crest leading up to the scene and warned approaching vehicles to slow down.

He did such a good job that police gave him the go-ahead to continue while they were on scene.

Senior Constable Bell said another person stopped and cut some of the limbs off the tree, which was hanging off the vehicle after the crash.

SES members attended to the rest of the tree.

Passers by held and soothed the children and gave them water, Senior Constable Bell said.

"The members of the public that assisted today, I thank them very, very much," she said.

She said the vehicle involved sustained major damage and had to be towed.

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