Night maintenance works are scheduled to start on the Calder Highway at Kangaroo Flat from Tuesday.
The Department of Transport has advised of lane closures southbound on the highway between Symes and Furness streets.
Traffic management will be in place nightly until Wednesday, March 17 between the hours of 7pm and 6am.
"For the safety of workers and the community we ask motorists to obey the 40km/h speed limit and to allow up to 10 minutes extra for their journey," the department said in a statement.
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