The Health Department on Friday confirmed the cases are linked to the Holiday Inn outbreak and have been quarantining at home during their infectious period, AAP reports.
A total of 22 confirmed cases have been connected to the outbreak, which can be traced back to a family of three staying on the third floor at the Holiday Inn at Melbourne Airport.
At least 15 cases have been shown to have the B117 variant through genomic testing.
About 3400 close contacts of positive cases remain in isolation and authorities had been warning more cases were likely to emerge.
The new infections bring the total number of active cases in the state to 27.
Some 21,292 people were tested on Thursday.
It comes as three Victorian hospitals have been chosen to distribute the state's first doses of the Pfizer vaccine to frontline workers.
Health Minister Martin Foley has announced Austin Health, Monash Health and Western Health will be the first to deliver doses of the vaccine from Monday.
He said hotel quarantine workers, airport and port workers, high-risk frontline health staff and aged care staff and residents will be first in line for the jab.
"Our priority is to support the Commonwealth to make sure that the vaccine is administered to workers at the highest risk of contracting COVID-19 as quickly and safely possible," Mr Foley said in a statement on Friday.
"Whether they work in hotel quarantine, at the airport or a specialist COVID ward - we need to keep Victorians most at risk of infection safe, while they continue to keep Victorians safe."
The vaccine will be administered at dedicated hospital facilities, in hotel quarantine settings, at Melbourne Airport and through mobile outreach teams.
The federal government has allocated 12,000 doses of the Pfizer vaccine to Victoria in the first week of the program.
About 59,000 doses are expected in the first four weeks.
Two doses of the Pzifer vaccine are required at least three weeks apart and it must be stored and transported at -70C.
Rhonda Stuart from Monash Health told reporters earlier this month the hospital had two freezers "ready and waiting" to store up to 180,000 doses.
Six other hospitals will also become vaccination hubs as more doses become available. They are Albury-Wodonga Health, Ballarat Health, Barwon Health, Bendigo Health, Goulburn Valley Health and Latrobe Health.
Mr Foley said the Barwon Health hub will begin its public sector residential aged care program next week, "trialling an outreach model to be implemented across regional Victoria".
Barwon Health will also vaccinate port of entry workers in Portland, in the state's southwest.
Meanwhile, anyone with COVID-19 symptoms in Boronia, Carrum Downs, Caulfield, Langwarrin, St Kilda East and Wantirna South has been urged to get tested after viral fragments were found in sewage this week.
Along with aged care residents, the state government will vaccinate hotel quarantine and health hotel workers, airport and port workers and high-risk frontline health staff first.
The Barwon Health hub will trial the model set to be implemented in regional Victoria when it begins its aged care vaccinations from next week.
It means hubs at Albury-Wodonga Health, Ballarat Health Services, Bendigo Health, Goulburn Valley Health, and La Trobe Regional Hospital will begin operating in the coming weeks.
The federal government has allocated 12,000 initial Pfizer vaccine doses for the first week of operation at hospital vaccination hubs. It will then provide 59,000 doses to Victoria over the first four weeks.
"Our priority is to support the Commonwealth to make sure that the vaccine is administered to workers at the highest risk of contracting COVID-19 as quickly and safely possible," Victorian health minister Martin Foley said.
"Whether they work in hotel quarantine, at the airport, or a specialist COVID ward - we need to keep Victorians most at risk of infection safe, while they continue to keep Victorians safe."
Three new coronavirus cases have been recorded in Victoria overnight.
The cases have all be locally acquired. More details are expected to be made clear later this morning.
It means there are now 27 active COVID-19 cases in Victoria.
Overnight, 21,292 test results were received by Victorians as the state came out of it's five-day lockdown.
When Bendigo's Pfizer vaccine hub receives its first doses next week, the region's aged care facilities in East Bendigo, Ironbark and Long Gully will be among the first to receive it.
About 240 nursing homes have been chosen for the first week of vaccination, due to begin on Monday, including those in the Bendigo area.
Health workers will be dispatched to vaccinate all aged care and disability residents over the next six weeks.
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