There are no restrictions on reasons to leave home or distance that can be travelled by Victorians from Monday, following an announcement by Premier Daniel Andrews.
The "ring of steel" separating regional Victoria and metropolitan Melbourne has been removed and is one of a number of changes to the state's COVID-19 roadmap, announced on Sunday.
The number of people permitted at private gatherings, religious ceremonies and hospitality venues has been increased statewide, while indoor entertainment venues such as museums, galleries and cinemas will reopen for the first time in months.
Mr Andrews said Victoria is on track to have a COVID normal Christmas, but stressed vigilance in the wake of the ninth consecutive day with no new coronavirus cases or deaths.
"Nine days of no cases isn't the same as a vaccine," Mr Andrews said.
"Each of us has a part to play in protecting what we have.
"If we want to stay open, we have to stay safe."
Health Minister Martin Foley said that for the first time since March, there are no active cases among Victoria's healthcare workers.
"That is a substantial milestone, given there were 3574 COVID-19 cases among healthcare workers," Mr Foley said.
The state government's coronavirus compliance blitz, announced on Saturday, has already resulted in 36 infringement notices being issued.
"The overwhelming majority of businesses are doing the right thing, but there are too many instances of businesses not doing the right thing," Mr Foley said.
From 784 visits, authorised officers discovered 121 instances of non-compliance, resulting in 14 warnings, 47 follow-up visits and 36 infringement notices.
The breaches include businesses and hospitality venues failing to have adequate hygiene provisions, incomplete contact registers, lack of signage and breaches of density quotas.
Mr Andrews said Victorians would be asked to continue to wear masks, but that a time will come when that may change.
"That is not for today and not for speculation," he said.
"Masks are low cost, high benefit and act as our insurance policy."
With four active COVID-19 cases statewide, Mr Andrews said the State of Disaster has not been renewed, a clear indication that things have improved in Victoria.
The State of Emergency will remain until at least December 6, to allow for the Chief Health Officers' directions to be enforced.
Restrictions are expected to ease again from November 23, where gathering limits will increase and patron caps and quotas will rise at hospitality and recreation venues.