A Bendigo Highway Patrol officer says it is "very disappointing" to see how many motorists continue to drive after drinking or taking drugs.
Police in the Bendigo division - which covers central Victoria - detected more than 200 offences on the region's roads in the first few days of Operation Saturn, which kicked off last Thursday.
Twenty-four motorists were found drink-driving or drug-driving.
"The number of people getting caught for drink and drug-driving is very disappointing," Senior Sergeant Ian Brooks said.
The region saw no fatal crashes, Senior Sergeant Brooks said, although there were five serious injury crashes, in which someone involved was taken to hospital.
He said police in the division had worked about 1100 hours since Thursday and conducted almost 600 preliminary breath tests.
Senior Sergeant Brooks said he anticipated the ability of officers to patrol the region's roads would easily increase two-fold once the border between Melbourne and regional Victoria came down, and checkpoints were not longer in place.
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Police had managed the extra workload posed by the checkpoints, he said, largely through the dedication of all officers to continue road policing and enforcement work.
Senior Sergeant Brooks said those who worked on the checkpoints had also continued to patrol while travelling to and from their locations.
He said everyone had "really pitched in" to ensure everything that could be done, was done.
Senior Sergeant Brooks also believed most people in regional Victoria had done the right thing, reducing the workload for police on the roads.
With the state beginning to open up again, Senior Sergeant Brooks said people should go out and enjoy themselves, but warned them not to drive if they had been drinking or taken drugs.
Operation Saturn continues until Sunday, November 8.