Police have confirmed two people have died in a multi-vehicle collision in Harcourt North on Friday night.

A further three people have been taken to hospital with non-life-threatening injuries.

More on that crash, here.

11pm

BENDIGO SES received about 25 requests for assistance in less than three hours this evening, all of which were weather-related.

The calls started coming through about 8.15pm, with Kangaroo Flat and Golden Square among the worst affected suburbs.

Bendigo SES deputy controller Natalie Stanway said some calls had been about properties or areas threatening to flood. In other cases, water was entering buildings.

The Bendigo unit had been called out to two rescues, one of which was a person trapped in a vehicle in flood water in Kangaroo Flat.

Ms Stanway said the Marong SES unit had a call of a similar nature.

"I believe there's been at least one more in the region, as well," she said.

Bendigo SES units were on scene at a serious multi-vehicle crash at Harcourt North, which happened about 9pm.

"We've still got crews out at that scene, which means our ability to get to those other jobs around Bendigo are going to be delayed," Ms Stanway said.

She said flooding around the Bendigo Creek area was something those who had been living in the area for a while knew to expect during heavy downpours.

"That's the nature of what we get around Bendigo, is flash flooding," she said.

Ms Stanway said flash flooding presented a challenge for crews because of how rapidly the water hit and dissipated.

She encouraged people to prepare for the possibility of flash flooding in terms of whether they needed to do some drainage work around their property, or to contact their local council about.

In the meantime, should they encounter flood water while driving, Ms Stanway said people should always make the safe decision and turn around and find and alternate route if they possibly could.

9.30pm

EMERGENCY services are responding to a serious, multi-vehicle crash at Ravenswood South.

Units were called to the intersection of the Calder Freeway and Fogartys Gap Road shortly before 9.30pm.

Earlier

EMERGENCY services have been called to a number of Bendigo locations in the past hour amid concerns of flooding and fire.

It comes as rain continues to fall in and around the city.

Five trucks responded to reports of a house fire at Ridge Road in Junortoun about 8.12pm.

The fire was under control in 15 minutes.

A Country Fire Authority said the five units were from Junortoun, Strathfieldsaye and Bendigo responded.

Firefighters are also responding to reports of flooding affecting buildings and roads, particularly in the Kangaroo Flat area.

Have you signed up to the Bendigo Advertiser's daily newsletter and breaking news emails? You can register below and make sure you are up to date with everything that's happening in central Victoria.