Senior Sergeant Ian Brooks said data showed more people were failing to use seatbelts in the Bendigo region.

"We have noticed a spike in the number of people detected not wearing seatbelts and we will be making a localised effort to (reduce that number)," he said.

"Our data shows at serious collisions, a seatbelt not being worn. Whether that is a deliberate act or a general attitude, we don't know. I have no idea why someone wouldn't wear a seatbelt.

"Why take risk of getting hurt? You're not invincible. The attitude of people in some cases amazes me."

Senior Sergeant Brooks' comments come after Operation Amadeus undertaken by Melbourne Highway Patrol in Bendigo at the weekend showed four people were caught not wearing seatbelts and eight people were found using mobile phones while driving on the Calder Freeway.

"Those are two of the most disappointing stats (from the operation)," he said. "That to me is ludicrous behaviour anywhere but driving down highway at 100km/h and talking on phone or not wearing a seatbelt, I cannot fathom why people have this behaviour."

Between Friday and Monday, Operation Amadeus detected 311 offences including more than 160 people speeding at least 10km/h over the limit.

Eighteen people were found to be driving while drunk or affected by drugs and 33 defective vehicles were found.

"Because of the issues we have had in area in the last 12 month in relation to fatal and serious collision, we welcomed the extra visibility and enforcement support," Senior Sergeant Brooks said.

"We had a lot of staff committed to working at the Southern 80 and Melbourne Highway Patrol came up and helped us.

"When you average it out, it comes to almost 80 (detected offences) a day, which is not a high number for that operation but it is disappointingly high for this part of he world."