Works to upgrade three sections of the Bendigo-Sutton Grange Road will start on January 28.
About three kilometres of road will be upgraded, including the 650 metres from Grays Road to the Mount Alexander Shire boundary, the kilometre from Ontario Lodge Lane to Faraday-Sutton Grange Road, and 1.2 kilometres near Jennings Hill Road South.
The $1.78 million project is expected to be completed by April.
The Mount Alexander Shire council said access to properties would be maintained at all times and affected residents would be informed of the works via mail.
Read more: Bendigo-Sutton Grange Road set for upgrades
There would also be traffic delays as part of the upgrade, the council said.
The average daily traffic volume on Bendigo-Sutton Grange Road in 2018 was 1123 cars per day.
Usage has increased by 55 per cent in four years.
The project was jointly funded through Regional Roads Victoria's Fixing Country Roads Program and the Federal Roads to Recovery Program.
Macedon Ranges councillors voted at their December meeting to award the contract to Bitu-Mill Civil Pty Ltd - the same company that upgraded other sections of the road in 2016.
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