While Australia Post sends them into retirement after their time is up, many are now enjoying a new life as people discover how much fun they are to ride.

When John Hazeldene attended a postie bike race event in another town, he immediately thought how Bendigo could grab the idea and do it bigger and better.

Mr Hazeldene put his hand in his own pocket and purchased a total of 98 ex-Australia Post bikes with a view to selling them on to locals ahead of a Motopostie Grand Prix set down for December 1.

The response has been amazing, and to date, Mr Hazeldene only has three bikes left.

With the proceeds of a small profit from the sale of each bike, sponsorship from local businesses and entry fees for riders and spectators, it's hoped a target of $100,000 will be raised for Bendigo Health via their new Wellness Centre for local cancer patients.

"I thought straight away Bendigo could do this," Mr Hazeldene said.

"I knew it would be fun to do it on a tight track at the go-kart track."

He quickly realised he would have no problem reaching his target of around 60 entries.

"I think some people thought I was mad when I bought all the bikes, but they've been snapped up so fast. A lot of people who enjoy racing bikes are realising how much fun postie bikes can be."

There will be a variety of events on the day, including a novice race, 30 lap race and team races.

Competitors in the major races will be timed prior and put into classes.

Competitor Mark Buckell said word is catching on that riding posties is lots of fun and more challenging than many "serious" riders expect.

"Until they've had a go people don't realise they're a bit harder to ride than a normal bike," he said.

"They are great for younger ones as well. The smaller you are the faster you can go."

A couple of big names will be attending the day; Laura Brown, a current leading contender for the 2019 Australian Supersport 300 championship and Marty Craggill, a former Australian Superbike champion.

Hazeldenes is pledging $10,000 as a major sponsor, and is encouraging other local businesses to get on board to support the event.

For those wanting to take part, entries are closing soon, and you must have your own bike and leathers.

A second practice day will be held this Sunday at the go-kart track - entry is free.

Early bird tickets for spectators for Motopostie GP for a Cause can be purchased for $7.70 a head from Bendigoregion.com.au

More information can be found on the Motopostie GP for a Cause facebook page