The crash occurred just before midnight on Skyline Drive near the intersection of Aurora Close when the driver's car left the road and hit a tree.

Two male passengers were also injured in the crash with a 19-year-old man with pelvis injuries taken by road ambulance to the Royal Melbourne Hospital in a stable condition.

A 24-year-old man with leg injuries was flown by air ambulance to the Royal Melbourne in a serious condition.

Police are calling for anyone who witnessed the collision or with dash cam footage to contact them.

Anyone with information should contact Crime Stoppers on 1800 333 000 or submit a confidential crime report at www.crimestoppersvic.com.au

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