Crews from Regional Roads Victoria worked through the day with the CFA to remove the sticky residue from the Calder HIghway.

With assistance from Loddon Shire and police, high-pressure hoses were used to sweep the molasses into a blocked off table drain to contain any further spillage.

Vacuum trucks will return at about 8am tomorrow and work to mid-afternoon to complete the clean up.

Traffic control will remain in place during the clean-up with drivers reminded to ober speed limits and drive to road conditions.

Tuesday, 6pm: The Calder Highway between Wedderburn and Bridgewater has re-opened after the truck rollover.

3.30pm: VicRoads has advised the Calder Highway at Wedderburn will remain closed for at least two more hours.

Two CFA units remain on scene working the EPA with clean up the highway.

The truck rollover occurred between Monument Drive and Inglewood-Korong Vale Road this morning with crews on scene cleaning up a mixture of molasses and diesel fuel.

"The latest from crews in the area is it will be another couple of hours before the road re-opens. Likely after 5.30pm," a VicRoads spokesperson said.

"There is a substantial detour in place adding half an hour onto the journey between Wedderburn and Bendigo."

The detour takes drivers from Wedderburn down Logon-Wedderburn Road to Logan before turning onto the Wimmera Highway toward Tarnagulla.

At Tarnagulla, drivers can either follow the Wimmera Highway to Newbridge and Marong or follow Bridgewater-Dunolly Road to Bridgewater.

12.30pm: The EPA is assisting the CFA with the clean-up. It is believed the molasses has combined with about 100 litres of diesel fuel.

11.20am

Molasses sprayed 10 metres high and landed in trees along the roadside during the crash.

A strong smell of diesel and molasses hangs in the air.

The truck is being moved, but Police expect the Calder to remain closed near Wedderburn for four to five hours.

The crash has left diesel and molasses across both lanes.

The Environmental Protection Authority is en route to assess the situation.

The truck was travelling northbound when it drifted onto the wrong side of the road and the driver lost control, Tarnagulla's Leading Senior Constable Dennis Farrell said.

The truck hit a number of trees and took out branches before rolling, he said.

The truck was the only vehicle involved in the incident.

A 58-year-old man has been taken to hospital with cuts, abrasions and bruises.

10.30am

An extensive clean-up operation is underway as molasses leaks onto the Calder Highway following a truck crash.

The Calder is closed in both directions following a crash between Wedderburn and Bridgewater, VicRoads says.

Detours have been set up between those two points with emergency services on scene directing traffic.

Melbourne-bound traffic is being diverted onto Logan-Wedderburn Road to the Wimmera Highway.

Traffic heading towards the north-west of the state is being diverted onto Bridgewater-Serpentine Road.

A truck is involved in the crash with investigations and extensive clean up of the area underway, VicRoads says.

Allow plenty of extra time around the area, the traffic authority is advising.

If you see any hazards on our roads, report them to the VicRoads Traffic Management Centre on 13 11 70, open 24/7, VicRoads advises. In an emergency, call Triple Zero.

10.25am

ONE person is being taken to hospital in Bendigo after this morning's crash.

Paramedics assessed one person at the scene, who looked to be in a stable condition, an Ambulance Victoria spokesperson said.

It did not appear that there were any serious injuries, the spokesperson said.

Earlier:

A TRUCK is blocking one lane of the Calder Highway near Wedderburn.

One person is believed trapped, a CFA spokesperson says.

The truck is blocking the southbound lane and police are directing traffic.

Four CFA trucks are on scene and the SES has been dispatched, the CFA spokesperson said.

The VicEmergency website has located the incident on the Calder Highway near Monument Drive.

Emergency crews were called at 9.34am.

More to come.

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