Detours are in place near Napier Street, White Hills, as part of works to upgrade the road.
Holdsworth Road will be closed in both directions between Napier and Raglan Streets From Monday March 18, until late this month.
Detours will be in place along Plumridge and Raglan streets.
Powell Street will be closed in both directions from 9am, Monday March 18 to 5pm, Wednesday March 20. This will allow for day works between Napier and Bobs streets.
Drivers travelling south towards Bendigo who want to turn left into Powell Street can travel along Baden and Bobs streets.
Those travelling north who want to turn right into Powell Street should turn right at Lyons Street and travel along Dundas Street.
Heavy vehicles can travel along Hamelin and Heinz streets in both directions.
Traffic controllers will be on site to monitor traffic flow and guide drivers around the worksite to make sure disruptions are kept to a minimum.
Speeds will be set at 40 kilometres per hour.
Works are weather dependent which means dates and times may change.
VicRoads thanked the community for their patience during the upgrades of Napier Street.
Traffic information can be found at: traffic.vicroads.vic.gov.au.
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