Kane Richardson (3-26) and Mohammad Nabi (4-25) led the onslaught as they restricted the home side to 9-115 before sauntering to victory in 13 overs in front of a crowd of 16,281.

Nabi finished the game off in fitting fashion when he launched Steve O'Keefe for a massive six over extra cover.

Tom Cooper looked to be cruising to a half-century before being clean bowled by O'Keefe for 49 - however the damage was already done.

Not only did the Renegades jump from fifth into second spot, it was an important bounce back after being flogged by the Brisbane Heat by 101 runs just three days earlier.

The Sixers' night was summed up when Jack Edwards dropped a sitter at mid-on to give Cameron White (16 not out) another life in what was his first game since being dropped in early January.

Earlier, Richardson and Nabi tore through the dismal Sixers.

While the pitch exhibited plenty of variable bounce, the Sixers' shot selection was poor - failing to go after balls that were there to be hit with several of their key batsmen dismissed in disappointing fashion.

Tom Curran (44) was the only batsman to pass 20 and one of only four to make double digits.

Richardson started the steady flow of wickets in the second over when Daniel Hughes (0) dragged him onto his stumps.

The 27-year-old showed few ill-effects from the hamstring injury that kept him out of Sunday's loss to the Heat as he took the key wickets of Hughes, Moises Henriques (3) and Jordan Silk (12).

The Sixers were 3-20 after the power play and couldn't get themselves into their innings, and they only passed 100 because of the efforts of Englishman Curran.

"It's hard against these guys because last time we did that against these guys, they defended it," Richardson said of the Sixers' 33-run win against the Renegades in late December.

"It's just nice to be back on the winner's list."

Curran refused to blame the pitch for the loss, saying his side handled the conditions poorly.

"It was tough work up top but any time you're 3-20 after the power play, it's going to be tough to come back from that," he said.

"(The pitch) played a part but that's the game, you've got to adapt and we weren't able to do that tonight."

Australian Associated Press