Operation Regal, which started on Friday, will run until midnight on Monday and will target the main factors contributing to deaths on Victorian roads - drugs, alcohol, speed, seatbelts, mobiles and fatigue. 

Bendigo Highway Patrol Sergeant Geoff Annand said the message to motorists was simple - slow down. 

"The key message this weekend is for motorists to slow down and take their time," he said.

"We want them to be courteous on the roads and drive safely.

"Police will be out in force all long weekend enforcing the road laws."

Sergeant Annand said a greater volume of traffic on the roads increased the risk of a serious accident.

"People just need to slow down and be patient," he said. 

"It is not worth it to rush." 

Four central Victorian men were killed and three seriously injured in a horror crash near Elmore during the Labor Day weekend in March.

Police said drugs, alcohol and irresponsible driving were contributing factors in the collision. 

Sergeant Annand said the public could help police keep the roads safe by reporting reckless driving. 

"If members of the public see dangerous driving, get on to triple 000 and report it," he said. 

"We want the public to be proactive.

"We are talking really serious stuff - excessive speeds, erratic driving or possible drug or drink-drivers.

"There is a finite number of police are out there and members of the public are driving on the roads all the time.

"They can be our eyes and ears and report these dangers.

"We do get reports all the time and we do follow them up."

The state's road toll sits at 110 this year compared with 103 last year. 

The State Emergency Service will set up its Driver Reviver sites this long weekend.

SES unit member Greg Cheyne said a site would be erected in Marong offering motorists a rest. 

"People can stop, have a chat and a look at the rescue trucks while at the same time have a break," he said.