Witnesses told police a wagon heading south on the Omeo Highway hit a ute travelling north at about 4.55pm.

The driver of the wagon, believed to be a woman in her late teens, and her female passenger, also believed to be in her teens, died at the scene.

The driver of the ute, believed to be a man in his 60s, was airlifted to the Alfred Hospital in a critical condition.

There are four bushfires burning in the vicinity of the crash as well as a severe weather warning for high winds, but it is not yet known if the conditions played a role in causing the crash.

Police are investigating the cause of the crash and urged witnesses or anyone with further information to contact them.

/**/