The two-time WNBL grand final MVP said the Spirit were hellbent on atoning for an "eye-opening" 41-point loss in Perth last weekend.

They will get fewer bigger opportunities to do that than against a Sydney Uni team predicted by many WNBL experts to go deep into the finals.

The Flames have beaten Bendigo twice this season in a pair of nail-biters, with the Spirit getting one back on their rivals by 15 points just before the Christmas break.

Griffin said whichever way you looked at it, the Flames game was massive.

"I hate to say it because every game feels like it's the biggest game of the year this year, but this one is going to be season defining," she said.

"That's not to say if it doesn't go our way our season is over by any means, but we can really put ourselves in a good position."

The Spirit head into the clash in third spot with a similar 10-6 record to Perth (second) and Sydney (fourth).

Dandenong is a win clear in top spot.

The Flames have every reason to be wary of Griffin, who by her own admission was below her best in Perth, going 0-8 from the floor to finish with five points.

The two-time WNBL All-Star described last week's game as a good wake-up call.

"One of the things I am working on this year is trying to get the team going and I probably didn't get myself into positions to make myself successful and do enough she said.

"It was such a weird game to be a part of, but in saying that I know my game better than to shoot five-threes.

"I need to get to the basket and I need to get to the free-throw line more and have more of an attacking mindset.

"I probably played a bit too much into Perth's hands to guard me, but it was a good wake up call for myself."

With the Flames playing Adelaide Lightning on Thursday night, Friday night’s game will be their third in six days.

The Flames will regain gun import Asia Taylor and Belinda Snell, who missed the teams' last encounter, while Kerryn Harrington is out for the Spirit.

Coach Simon Pritchard hoped the Spirit could take advantage of the Flames' heavy schedule.

The second-year coach sensed plenty of determination and fire in the belly of his players during the week in the wake of last week's loss.

"There was almost a sense of anger in them at training on Tuesday night," he said.

"But that anger needs to be converted to positive actions to attack Sydney.

"We need to transfer that from training into the game.

"A win here is a double-win because a win give us the split over Sydney in a tie situation and we'll stay above Sydney."

Blake Dietrick will assume the starting point guard role in Harrington's absence, with the US import earning praise for her application and work-rate during practice this week.

"Even though it was a rough loss in Perth I gained a lot respect for the way Blake handled herself," Griffin said.

"We didn't have anyone else on the bench and she just stuck to it and rode it out.

"She's really competitive and I'm excited to see how she steps up and I know she's going to do well."

Tip-off on Friday night is at 7.30pm.