Police investigating the hit-and-run collision are searching for three people who ditched the car and ran away from the scene.

Two women in their 30s were pushing a pram with two children in it - aged two years old and eight months old - when they were struck by a car on Grand Boulevard in Craigieburn just before 10am on Monday.

An Ambulance Victoria spokeswoman said one of the women and a young boy had been taken to the Northern Hospital in stable conditions and nobody had serious injuries.

The other woman and a young girl were assessed at the scene.

Leading Senior Constable Adam West said investigators had been told the car was a white Nissan skyline.

"Three occupants of the car, believed to be two men and a woman, left the car at the scene and fled on foot," he said.

Police are investigating the cause of the incident.