UPDATE: A police spokeswoman confirmed the Wedderburn house was not occupied at the time of the fire.
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Police are continuing to investigate the fire with the Arson Squad expected to arrive on the scene this afternoon.
"Detectives on the scene will investigate. The cause is still unknown at this stage," the spokeswoman said.
"Anyone with information about the fire should contact crime stoppers."
EARLIER: CFA investigators are looking into the cause of a house fire in Wedderburn.
The fire started last night at 11.05pm.
Four CFA crews attended the fire and took an hour to control the blaze.
A CFA spokesman said the house was well alight when crews arrived.
"The house was 80 per cent involved and almost completely destroyed," he said.
"There were no people there and no injuries. The cause is undetermined at this stage."
Fire investigators will look at the cause of the fire this morning.
Police said the fire reignited at around 8am. CFA crews controlled the reignited fire quickly.