A 33-year old man from Cranbourne North died when his car ran off the road and hit a tree about 6.30 at Myola, north-east of Bendigo.

Leading Senior Constable Niall King of Bendigo Highway patrol said ambulance officers attended but the man was deceased when they arrived.

He said the man was travelling north when he ran off the right-hand side of the road. 

"He's travelled on gravel for about 100 metres and corrected left, crossing the road again and hitting a tree," Leading Senior Constable King said.

"It was dark, foggy and wet on the road.

"We a wonder if fatigue could have been a factor."

 Leading Senior Constable King said there was no evidence of kangaroos and no skid marks on the road. 

The man was the Mercedes sedan's only occupant and it is not known where he was travelling.

The Northern Highway was closed between Toolleen-Axedale Road and Bendigo-Murchison Road for several hours.

SES and CFA crews also attended.

Leading Senior Constable King reminded people to drive to conditions and to rest when tired.

Police are also investigating the circumstances surrounding a fatal car crash at Springhurst, near Wangaratta, Wednesday afternoon. 

Investigators believe that the car was travelling south on the Hume Freeway when it ran off the road during an ice storm and crashed into a tree. 

All four occupants were taken to hospital and an 87-year-old Wangaratta woman, who was a passenger in the car, died later that evening. One of the other passengers suffered life-threatening injuries.

The provisional road toll for 2014 is 133. This time last year it was 120.

Anyone with any information surrounding the crashes is urged to contact Crime Stoppers on 1800 333 000 or visit www.crimestoppersvic.com.au 

EARLIER UPDATES:

UPDATE, 1.50pm: The Northern Highway is reopened to traffic following a fatal crash early this morning. Police are still investigating the cause of the single-vehicle accident.

UPDATE, 1.25pm: A man who died when his car hit a tree at Myola this morning is from Cranbourne North.

He was driving a white Mercedes sedan.

The provisional road toll for 2014 is 133. This time last year it was 120.

Leading Senior Constable Niall King of Bendigo Highway Patrol reminded people to drive to conditions and to rest when tired.

Anyone with any information surrounding the crash is urged to contact Crime Stoppers on 1800 333 000 or visit www.crimestoppersvic.com.au 

UPDATE 9.48am: Police will continue to investigate the cause of the crash.

Leading Senior Constable King said there were no skid marks on the road.

He said ambulance officers attended but the man was deceased when they arrived.

It is unknown where the man was travelling.

The Northern Highway remains closed between Toolleen-Axedale Road and Bendigo-Murchison Road.

UPDATE 9.30am: A 33-year-old man has died after the car he was driving hit a tree on the Northern Highway at Myola about 6.30 this morning.

Leading Senior Constable Niall King said the man was travelling north when he ran off the road on the right-hand side.

"He's travelled on gravel for about 100 metres and corrected left, crossing the road again and hitting a tree," Leading Senior Constable King said.

"It was dark, foggy and wet on the road.

"We also wonder if fatigue could have been a factor."

Leading Senior Constable King said there was no evidence of kangaroos but they were regularly involved in accidents in the area.

The man was from Melbourne.

UPDATE 9.10am: A 33-year-old male has died after the car he was travelling in hit a tree on the Northern Highway this morning, police have confirmed.

UPDATE 7.30am: Ambulance Victoria spokesman John Mullen said a man in his 30s was trapped after his car hit a tree.

The crash happened at the intersection of the Northern Highway and Bickley Road, Myola.

Mr Mullen said Ambulance Victoria received the call at 6.38 this morning and officers attended to treat the man.

EARLIER:

EMERGENCY services including the CFA are responding to a road accident at Myola on the Northern Highway.

There are at least three vehicles attending the scene, north-east of Bendigo.

A CFA spokesman said a car had hit a tree.

"Two CFA units, an SES unit and an ambulance are on scene," he said.

"At this stage it appears one person is trapped."