Wimmera had the game sewn up at half-time on the way to its 21.15 (141) to 11.11 (77) victory.

Having led by nine points at quarter-time, Wimmera put its foot down in the second term when it slammed on 7.3 to 0.2 to open up a 52-point break at half-time.

"They were just too fast and skilful for us today," North Central coach James Coatsworth said.

"They had plenty of class in their side and their pressure on us was relentless all game and unfortunately, the game was over at half-time.

"There was a good crowd there and a nice day for footy, so it was obviously a very disappointing result."

North Central had a star-studded forward line featuring captain Sam Barnes, Brady Herdman, James McNamee, Nicholas Coghlan and Ricky Allan, but the side could muster just three goals in the first half - all from Barnes - before adding eight in the second.

North Central kicked three of the first four goals of the final term to close within 33 points, but Wimmera responded to the challenge, finishing the match with six of the last seven goals.

Defender Rohan McHugh - one of 11 Wedderburn players in the side - was the best for North Central, which suffered its first inter-league loss since 2011.

"Rohan was put under a lot of pressure and was probably the only player who stood up in the first half," Coatsworth said.

"He worked really hard for four quarters."

Rover Mark Lloyd in his first North Central inter-league game performed well, particularly after half-time, while defenders  Aaron Wilson and Hayden Polglase were also among the best.

Cameron Perry was another who played well for North Central.

"We put Cam in the middle in the second half and he played really well and got things going for us a bit," Coatsworth said.

Barnes (four) and Herdman (two) were the multiple goalkickers for North Central, which dropped to No.19 in the AFL Victoria Country rankings and next season will play Geelong District for the second time in three years.

The win was Wimmera's first inter-league victory since 2009.

"We set ourselves for this six weeks ago, and the way we played you couldn't be any happier," Wimmera coach Louie Dalziel said.