The Bloods - who had Tyack and Neale Torpey take over as co-coaches from Jeff Brennan on Monday night - meet Kangaroo Flat at the Queen Elizabeth Oval in round six.

"Myself and Neale are very pleased with how training has gone this week, so we're looking forward to getting out there on Saturday and putting in the best effort we can against Kangaroo Flat," Tyack said on Friday.

"We've put everything behind us and moved forward."

The Bloods are 0-5, which includes two tight losses against Kyneton (eight points) and reigning premier Golden Square (one).

"We've had a number of new players in the group, and with our training this week, the boys have really embraced the gameplan and structures that Neale and I want," Tyack said.

"The group is just really keen to get out there on Saturday and have a good game and see if we can get our season under way.

"We've had a couple of games where it could have gone either way and there's some terrific talent in the group, but this week is about drawing a line in the sand, playing our best footy and seeing where that takes us."

The Bloods have been boosted by the inclusion of the Bendigo Gold trio of ruckman Jeremy Lambden and midfielders Galen Munari and Liam Byrne.

Saturday is the second year in a row Kangaroo Flat has played an opponent following an in-season coaching change.

Last year the Roos were beaten by Castlemaine by 17 points in the week after the Magpies replaced Rod Keogh with Brett Fitzpatrick as coach.

"We saw last year when Castlemaine was in a similar situation and came out full of fire, and we'll be expecting nothing less from South Bendigo," Roos coach Jason Stevens said.

"But it's not just about what has happened with the coaching... South Bendigo's results aren't as bad as 0-5 suggests and we need to step up to the challenge after we were disappointing last week."

The Roos were last week comprehensively outplayed by the ladder-leading Sandhurst, kicking just four goals in a 107-point hiding - also at the QEO - in their second loss of the season.

"This weekend is huge for our season. We need to be really competitive and try to knock off those sides that are around our mark, and we certainly rate South Bendigo a side that is around our level," Stevens said.

"Last weekend wasn't good enough and we need to improve on that this week.

"After a big month of footy, hopefully, the boys were just flat last week and they can get back up for the challenge on Saturday."

Meanwhile, in the reserves, South Bendigo's Neville Clark will play his 200th club game for the Bloods on Saturday.