Police are currently on scene following the incident, which occurred just after 3.30pm today. 

"A Mazda sedan was travelling south on Mount Macedon Road when it collided with a motorcycle," a spokeswoman said.

"The male motorcyclist, who isyet to be identified, died at the scene. 

"No one else was injured. 

"The driver of the Mazda, a Woodend woman, is helping police with their inquiries."

Anyone who witnessed the collision is urged to contact Crime Stoppers on 1800 333 000 or visit www.crimestoppers.com.au 

3.50PM: A PERSON has been knocked off their motorbike in a collision with a car on Mount Macedon Road.

Ambulance crews are now at the scene.

Ambulance Victoria spokesman John Mullen confirmed they received the call at 3.26pm.

“It is between a car and a motorcycle,” he said.

“The helicopter has been paged.

“The crew have only just arrived on scene and they will assess the situation.”

More to come.