UPDATE 11.56AM: Wimmera Highway at Wilsons Hill has been reopened to traffic.
BENDIGO police are investigating the circumstances surrounding a fatal crash that claimed the life of a man in Wilsons Hill, near Bendigo, this morning.
Investigators believe the man was travelling along Wimmera Highway just after 4am when the car has crossed onto the other side of the road.
Highway Patrol Senior Sergeant Paul Gardiner said a truck driver came across the crash at 4.20am.
"We believe the driver was on his way home," he said.
The vehicle has hit a tree and the driver, who is yet to be identified, has died at the scene.
Police will prepare a report for the Coroner.
Anyone who may have information regarding the incident is urged to contact Crime Stoppers on 1800 333 000 or visit www.crimestoppers.com.au