Police arrested four people following a three month investigation into the trafficking of methamphetamine, heroin and cannabis in and around the Bendigo area.
Bendigo police, with assistance from the Special Operations Group and Critical Incident Response Team simultaneously executed the warrants around 1pm on Friday.
Two men and two women were arrested at the residential addresses.
North Bendigo man Lee Zarb, 35, was charged with trafficking methamphetamine, trafficking cannabis, being a prohibited person possessing a firearm and recklessley causing serious injury and other assault charges relating to a previous incident.
He appeared before a bail justice on Friday night where he was remanded in custody to appear before Bendigo Magistrates' Court on Monday.
A man in his early 20s was charged with possessing methamphetamine and bailed to Bendigo Magistrates' Court at a later date.
A woman in her early 20s is expected to be charged on summons for durg related offences and another woman in her early 20s received a drug caution.
The investigation is ongoing.
In other police news, a man who held up the Gisborne Subway store with a knife on Friday morning remains at large. At about 8.30am on Friday, the man entered the takeaway store armed with a knife.
He made demands for money, before fleeing the scene with a small amount of cash.
He was last seen running north on Atkins Street, Gisborne.
Police remain on the lookout for a Caucasian man in his late 20s to early 30s wearing a light hooded jacket and blue pants, who fled from the scene.
The Gisborne Crime Investigation Unit is investigating.
Anyone with information is urged to call Gisborne Police Station on 5428 2500.